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The most obvious differences between males and females include all the features related to reproductive role, notably the endocrine (hormonal) systems and their physiological and behavioural effects, including gonadal differentiation, internal and external genital and breast differentiation, and differentiation of muscle mass, height, and hair distribution.

The human genome consists of two copies of each of 23 chromosomes (a total of 46).

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Sex differences in human physiology are distinctions of physiological characteristics associated with either male or female humans.

These can be of several types, including direct and indirect.

Direct being the direct result of differences prescribed by the Y-chromosome, and indirect being a characteristic influenced indirectly (e.g. Sexual dimorphism is a term for the phenotypic difference between males and females of the same species.

Direct sex differences follow a bimodal distribution.

Through the process of meiosis and fertilization (with rare exceptions), each individual is created with zero or one Y-chromosome.

The complementary result for the X-chromosome follows, either a double or a single X.

Therefore, direct sex differences are usually binary in expression (although the deviations in complex biological processes produce a menagerie of exceptions).

These include, most conspicuously, male (vs female) gonads.

Indirect sex differences are general differences as quantified by empirical data and statistical analysis.